pharmacokinetics
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#1
16-06-2010, 06:53 PM


Abstract:
Pharmacokinetic is mainly dedicated to the determination of the fate of substances administered externally to a living organism. In practice this discipline is applied mainly to drug substances, though in principle it concerns itself with all manner of compounds ingested or otherwise delivered externally to an organism, such as nutrients, metabolites, hormones, toxins and Pharmacokinetic models are designed to forecast the evolution of an endogenous or exogenous component on the tissues. To follow-up the evolution of the contrast agent a sequence of MRI volumetric images is obtained at different times following the injection of contrast. Each of these images comprises a series of image slices that cover the body part explored. Since the whole process takes a few minutes, images are obtained in different break-hold periods. This movement of the patient produces artefacts that make images directly incomparable. This fact is even more important in the area of the abdomen, which is strongly affected by the breathing and the motility of the organs. It is important to ensure that the same voxel in all the volumetric images correspond to the same anatomic point in the patient
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